Shuimu Technology

We've developed unique tookits to excel in cryo-EM structure determination.

GraFuture™ 氧化石墨烯支撑膜

为了突破冷冻电镜(cryo-EM)样品制备的瓶颈,水木未来研发了一系列石墨烯载网支持膜——GraFuture™,为样品的优势取向问题提供了潜在的解决方案。
CryoEM at Shuimu CryoEM Center

挑战

传统冷冻电镜样品制备中的挑战

使用传统支撑网格进行冷冻电镜样品制备时存在以下问题:
气-液界面吸收
严重的优势取向
样品浓度阈值过高(>1μM)
背景噪音显著
难以重建“小型”大分子结构

GraFuture™ 载网产品

使用GraFuture™载网解锁效率和精度

Shuimu's GraFuture CryoEM GO & RGO Grid solving preferential orientation issues
GraFuture™ GO from Shuimu Biosciences

GraFuture™ GO

氧化石墨烯载网支持膜
GraFuture™ RGO from Shuimu Biosciences

GraFuture™ RGO

还原氧化石墨烯载网支持膜

为什么选择我们?

GraFuture™ 载网优势

选择GraFuture™载网,您将享有以下优势:
GraFuture™ Grids Advantages

规格

氧化石墨烯
还原氧化石墨烯

GraFuture™ From Shuimu Biosciences≤ 5 厚度
GraFuture™ RGO超薄 go/rgo类型
≥ 70 %覆盖率

性能亮点

与GraFuture™一起见证卓越

GraFuture™ GO from Shuimu BiosciencesGraFuture™ RGO from Shuimu BiosciencesGraFuture™ RGO from Shuimu Biosciences

案例研究

GO & RGO

Cell. 2022 Feb 17;185(4):630-640.e10.

GO

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2Cell. 2022 Feb 17;185(4):630-640.e10.
Read More
Nature. 2022 Jul;607(7918):399-406.

RGO

Structural insights into dsRNA processing by Drosophila Dicer-2-Lo- qs-PDNature. 2022 Jul;607(7918):399-406.
Read More
Nature. 2022 Apr;604(7905):377-383.

RGO

Structure deformation and curvature sensing of PIEZO1 in lipid mem- branesNature. 2022 Apr;604(7905):377-383.
Read More
Science. 2021 Jan 8;371(6525):eabe8863.

RGO

Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2Science. 2021 Jan 8;371(6525):eabe8863.
Read More
Shuimu's GraFuture CryoEM GO & RGO Grid solving preferential orientation issues

GraFuture™ GO/RGO Support Film

To overcome the bottleneck in cryo-EM sample preparation, Shuimu developed a series of graphene coated grids - GraFuture™, using them to achieve a better reproducibility and efficiency of cryo-EM sample preparation.

联系我们

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如需咨询我们的服务,请填写此表格,我们将很快与您联系。

见微知著

始于2017年,水木未来致力于推动基于冷冻电镜的新药研发。

联系我们

北京:北京市昌平区中关村生命科学园医药科技中心2号楼4层水木未来北京市昌平区中关村生命科学园北京生命科学研究所B1杭州:杭州市临安区大园路1623号010-52201018

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