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GPR75

The word‘s first cryo-EM structure of the promising anti-obesity target

Is published by Shuimu BioSciences

Cryo-EM complex structure of active GPR75 with a nanobody
CryoEM Scientists at Shuimu BioSciences

November 2023

Published in Molecular Cell

Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5November 22, 2023

Published in Nature Portfolio

Novel, broad and potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineagesNovember 13, 2023

Published in BioRxiv

An end-to-end approach for protein folding by integrating Cryo-EM maps and sequence evolutionNovember 5, 2023

October 2023

Published in Communications Chemistry

Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognitionOctober 28, 2023

Published in Nature Plants

Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt toleranceOctober 26, 2023

September 2023

Published in Nature Communications

Structural insights into the mechanism of GTP initiation of microtubule assemblySeptember 25, 2023

Published in ELife

Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architectureSeptember 22, 2023

Published in Nature Communications

Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signalingSeptember 22, 2023

August 2023

Published in Nature Communications

Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomersAugust 26, 2023

July 2023

Published in PNAS

Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EMJuly 24, 2023

Published in Science Advances

Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligaseJuly 14, 2023

June 2023

Published in Science

Reorientation of INO80 on hexasomes reveals basis for mechanistic versatilityJune 29, 2023

Published in Nature Communications

Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobodyJune 20, 2023

May 2023

Published in CellResearch

Structure and transport mechanism of the human calcium pump SPCA1May 31, 2023

Published in Nature Communications

Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4May 22, 2023

Published in Science Advances

Dodecamer assembly of a metazoan AAA+ chaperone couples substrate extraction to refoldingMay 10, 2023

April 2023

Published in Communications Biology

HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomographyApril 29, 2023

Published in Nature Communications

Conformational cycle of human polyamine transporter ATP13A2April 8, 2023

Published in ACS

Dual-Affinity Graphene Sheets for High-Resolution Cryo-Electron MicroscopyApril 3, 2023

March 2023

Published in Nature

Structural mechanisms for regulation of GSDMB pore-forming activityMarch 29, 2023

Published in Antiviral Research

Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/ Omicron variants following an inactivated whole-virus vaccineMarch 5, 2023

February 2023

Published in ACS Central Science

In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike ProteinFebruary 8, 2023

January 2023

Published in BioRxiv

Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocinJanuary 21, 2023

Published in Cell Research

The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulationJanuary 17, 2023

Published in Cell Discovery

Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5January 7, 2023

October 2022

Published in Mol Cell

Target RNA activates the protease activity of Craspase to confer antiviral defenseOctober 21, 2022

Published in Advanced Science

Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA PolymerasesOctober 20, 2022

September 2022

Published in Nature Chemical Biology

Molecular basis for the selective G protein signaling of somatostatin receptorsSeptember 22, 2022

August 2022

Published in BioRxiv

Cryo-EM complex structure of active GPR75 with a nanobodyAugust 18, 2022

Published in Protein & Cell

Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin AAugust 5, 2022

July 2022

Published in Molecular Cell

GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptorsJuly 21, 2022

June 2022

Published in Nature

Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PDJune 29, 2022

Published in National Science Review

Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animalsJune 23, 2022

Published in Science Advances

Structural insights into G protein activation by D1 dopamine receptorJune 10, 2022

Published in Nature Communications

Ligand recognition and biased agonism of the D1 dopamine receptorJune 8, 2022

May 2022

Published in PNAS

Structural insights into galanin receptor signalingMay 20, 2022

Published in Cell Reports

A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pikaMay 17, 2022

Published in Cell Discovery

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3May 15, 2022

April 2022

Published in Cell Reports

High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IVApril 26, 2022

Published in Nature

Structural basis for the tethered peptide activation of adhesion GPCRsApril 13, 2022

February 2022

Published in bioRxiv preprint

Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction February 25, 2022

Published in Nature Communications

Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2February 25, 2022

Published in Cell

Receptor binding and complex structures of human ACE2 to spike RBD from Omicron and Delta SARS-CoV-2February 17, 2022

Published in Journal of Virology

Structure of Rift Valley fever virus RNA-dependent RNA polymerase February 9, 2022

January 2022

Published in Cell Reports

A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2January 18, 2022

December 2021

Published in Journal of Biological Chemistry

Cryo-EM structure of mouse TRPML2 in lipid nanodiscsDecember 14, 2021

November 2021

Published in Scientific reports

Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activityNovember 25, 2021

September 2021

Published in ACS nano

Atomically Thin Bilayer Janus Membranes for Cryo-electron MicroscopySeptember 27, 2021

Published in Molecular Biomedicine

Fast and long-lasting immune response to S-trimer COVID-19 vaccine adjuvanted by PIKASeptember 27, 2021

Published in Nature

Structures of full-length glycoprotein hormone receptor signalling complexesSeptember 22, 2021

Published in Nature Structural&Molecular Biology

Molecular basis for kinin selectivity and activation of the human bradykinin receptorsSeptember 9, 2021

August 2021

Published in Cell Research

Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variantsAugust 26, 2021

July 2021

Published in Cell Discovery

Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutantsJuly 20, 2021

June 2021

Published in Neuron

Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptorsJune 28, 2021

April 2021

Published in Nature Communications

Cryo-EM structure of the human histamine H 1 receptor/G q complexApril 23, 2021

Published in Communication Biology

Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2April 23, 2021

March 2021

Published in Journal of Virology

Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19March 10, 2021

November 2020

Published in Immunity

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune ResponsesNovember 25, 2020

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