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揭示洞见：携手项目文章，共赴科学突破之旅
踏上知识发现之旅，见证我们突破性结构发现背后的精彩故事。我们精心汇编的项目文章将带您领略尖端结构生物学的魅力世界，触摸科学创新的脉搏。
GPR75
The word‘s first cryo-EM structure of the promising anti-obesity target
Is published by Shuimu
Cryo-EM complex strure of active GPR75 witch a nanbody
November 2023
Published in Molecular Cell
Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5
November 22, 2023
Published in Nature Portfolio
Novel, broad and potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages
November 13, 2023
Published in BioRxiv
An end-to-end approach for protein folding by integrating Cryo-EM maps and sequence evolution
November 5, 2023
October 2023
Published in Communications Chemistry
Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition
October 28, 2023
Published in Nature Plants
Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance
October 26, 2023
September 2023
Published in Nature Communications
Structural insights into the mechanism of GTP initiation of microtubule assembly
September 25, 2023
Published in ELife
Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture
September 22, 2023
Published in Nature Communications
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling
September 22, 2023
August 2023
Published in Nature Communications
Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers
August 26, 2023
July 2023
Published in PNAS
Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM
July 24, 2023
Published in Science Advances
Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase
July 14, 2023
June 2023
Published in Science
Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility
June 29, 2023
Published in Nature Communications
Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody
June 20, 2023
May 2023
Published in CellResearch
Structure and transport mechanism of the human calcium pump SPCA1
May 31, 2023
Published in Nature Communications
Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4
May 22, 2023
Published in Science Advances
Dodecamer assembly of a metazoan AAA+ chaperone couples substrate extraction to refolding
May 10, 2023
April 2023
Published in Communications Biology
HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography
April 29, 2023
Published in Nature Communications
Conformational cycle of human polyamine transporter ATP13A2
April 8, 2023
Published in ACS
Dual-Affinity Graphene Sheets for High-Resolution Cryo-Electron Microscopy
April 3, 2023
March 2023
Published in Nature
Structural mechanisms for regulation of GSDMB pore-forming activity
March 29, 2023
Published in Antiviral Research
Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/ Omicron variants following an inactivated whole-virus vaccine
March 5, 2023
February 2023
Published in ACS Central Science
In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein
February 8, 2023
January 2023
Published in BioRxiv
Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocin
January 21, 2023
Published in Cell Research
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation
January 17, 2023
Published in Cell Discovery
Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5
January 7, 2023
October 2022
Published in Mol Cell
Target RNA activates the protease activity of Craspase to confer antiviral defense
October 21, 2022
Published in Advanced Science
Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases
October 20, 2022
September 2022
Published in Nature Chemical Biology
Molecular basis for the selective G protein signaling of somatostatin receptors
September 22, 2022
August 2022
Published in BioRxiv
Cryo-EM complex structure of active GPR75 with a nanobody
August 18, 2022
Published in Protein & Cell
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A
August 5, 2022
July 2022
Published in Molecular Cell
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
July 21, 2022
June 2022
Published in Nature
Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
June 29, 2022
Published in National Science Review
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals
June 23, 2022
Published in Science Advances
Structural insights into G protein activation by D1 dopamine receptor
June 10, 2022
Published in Nature Communications
Ligand recognition and biased agonism of the D1 dopamine receptor
June 8, 2022
May 2022
Published in PNAS
Structural insights into galanin receptor signaling
May 20, 2022
Published in Cell Reports
A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pika
May 17, 2022
Published in Cell Discovery
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
May 15, 2022
April 2022
Published in Cell Reports
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
April 26, 2022
Published in Nature
Structural basis for the tethered peptide activation of adhesion GPCRs
April 13, 2022
February 2022
Published in bioRxiv preprint
Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction
February 25, 2022
Published in Nature Communications
Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2
February 25, 2022
Published in Cell
Receptor binding and complex structures of human ACE2 to spike RBD from Omicron and Delta SARS-CoV-2
February 17, 2022
Published in Journal of Virology
Structure of Rift Valley fever virus RNA-dependent RNA polymerase
February 9, 2022
January 2022
Published in Cell Reports
A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2
January 18, 2022
December 2021
Published in Journal of Biological Chemistry
Cryo-EM structure of mouse TRPML2 in lipid nanodiscs
December 14, 2021
November 2021
Published in Scientific reports
Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity
November 25, 2021
September 2021
Published in ACS nano
Atomically Thin Bilayer Janus Membranes for Cryo-electron Microscopy
September 27, 2021
Published in Molecular Biomedicine
Fast and long-lasting immune response to S-trimer COVID-19 vaccine adjuvanted by PIKA
September 27, 2021
Published in Nature
Structures of full-length glycoprotein hormone receptor signalling complexes
September 22, 2021
Published in Nature Structural&Molecular Biology
Molecular basis for kinin selectivity and activation of the human bradykinin receptors
September 9, 2021
August 2021
Published in Cell Research
Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
August 26, 2021
July 2021
Published in Cell Discovery
Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants
July 20, 2021
June 2021
Published in Neuron
Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors
June 28, 2021
April 2021
Published in Nature Communications
Cryo-EM structure of the human histamine H 1 receptor/G q complex
April 23, 2021
Published in Communication Biology
Structure and function analysis of a potent human neutralizing antibody CA521FALA against SARS-CoV-2
April 23, 2021
March 2021
Published in Journal of Virology
Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19
March 10, 2021
November 2020
Published in Immunity
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses
November 25, 2020
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